Does this mean "Anyway, you must be safe" or "Anyway, you are certainly safe"?
I think it is the former, but I am not sure.
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无论如何 means "no matter what"
The verb 要 means "need to be" here in this sentence, because it is followed by an adjective 平安(safe).
一定要平安 means " need to be safe for sure"
If the verb 要 is followed by a noun, for example 一定要一千美元, then 要 would simply mean "need" - "need $1000 for sure"
If the verb 要 is followed by another verb, then 要 would be a modal verb in the sentence, for example: "you need to kill him"