Or the 西 (xi1) in 东西 (dong1xi0) is pronounced with no tone?

  • for answers at this site search Q&A using e.g. "neutral tone"
    – user6065
    Sep 30 '17 at 23:46

No. It does not always apply.

xi0 might be another way of writing the neutral tone. I haven't seen it before.

For 东西, dong1xi1 (east and west) and dong1xi(thing) have different meanings.

To make sure whether a word ends with a neutral tone, without hearing how natives are using it, you'll have to look it up in a dictionary.

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