I was typing something in Chinese to a friend including 你这人 (or 你这个人), when I realized that I didn't have a good interpretation of it in English. It just feels like the sort of thing you say to somebody when you're pointing out something criticizable of theirs, but I don't know how to put it in words.
Something like this: 你这人,怎么能说那个乱话呢? (____, how can you say that messed-up stuff?)