The big characters look like 啻chì泰tài
啻 chì is a old word not common today I think.
泰 tài safe or peaceful calm also big (泰tài州zhōu is a city in Jiangsu province)
Together I don't know what they might mean.
As a guess, 啻 can mean 'remain, remainder'. (Jíyùn.zhìyùn is an 11th century dictionary)
啻: remain, left over. <Jíyùn.zhìyùn&...
The artist used two courtesy names in the piece:
One in the calligraphy, 新羅山人;
One in the seal, 秌（秋）𡵽（岳）.
The artist's real name is 「華嵒」 (Mandarin Pinyin: Huà Yán), a Qīng Dynasty painter.
Notes on seal character identification
In the seal,
「秋」 uses the variation 「秌」, where 「禾」 and 「火」 are switched around;
「岳」 is written with a shape like